Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

Many lines of evidence suggest that the Parkinson's disease (PD)-related protein α-synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the cellular mechanisms behind the spreading remain elusive. Here, we show that human astrocytes derived from embryonic stem cell...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Rostami, Jinar, Holmqvist, Staffan, Lindström, Veronica, Sigvardson, Jessica, Westermark, Gunilla T, Ingelsson, Martin, Bergström, Joakim, Roybon, Laurent, Erlandsson, Anna
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2017
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719970/
https://ncbi.nlm.nih.gov/pubmed/29089438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0983-17.2017
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