Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Parkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various brain regions is the major pathological hallmark. Indeed, the motor symptoms in PD are caused by a heterogeneous d...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Diógenes, Maria José, Dias, Raquel B., Rombo, Diogo M., Vicente Miranda, Hugo, Maiolino, Francesca, Guerreiro, Patrícia, Näsström, Thomas, Franquelim, Henri G., Oliveira, Luís M.A., Castanho, Miguel A.R.B., Lannfelt, Lars, Bergström, Joakim, Ingelsson, Martin, Quintas, Alexandre, Sebastião, Ana M., Lopes, Luísa V., Outeiro, Tiago Fleming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703775/
https://ncbi.nlm.nih.gov/pubmed/22915117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0234-12.2012
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