Age-Related Impairment of Synaptic Transmission But Normal Long-Term Potentiation in Transgenic Mice that Overexpress the Human APP695SWE Mutant Form of Amyloid Precursor Protein

We have studied synaptic function in a transgenic mouse strain relevant to Alzheimer's disease (AD), overexpressing the 695 amino acid isoform of human amyloid precursor protein with K670N and M671L mutations (APP(695)SWE mice), which is associated with early-onset familial AD. Aged-transgenic...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Fitzjohn, Stephen M., Morton, Robin A., Kuenzi, Frederick, Rosahl, Thomas W., Shearman, Mark, Lewis, Huw, Smith, David, Reynolds, David S., Davies, Ceri H., Collingridge, Graham L., Seabrook, Guy R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762352/
https://ncbi.nlm.nih.gov/pubmed/11425896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-13-04691.2001
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