Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APP(Swe)/PSEN1(M146V) transgenic mice

BACKGROUND: Progression of Alzheimer's disease is thought initially to depend on rising amyloidβ and its synaptic interactions. Transgenic mice (TASTPM; APP(Swe)/PSEN1(M146V)) show altered synaptic transmission, compatible with increased physiological function of amyloidβ, before plaques are de...

Full description

Saved in:
Bibliographic Details
Published in:EBioMedicine
Main Authors: Medawar, Evelyn, Benway, Tiffanie A., Liu, Wenfei, Hanan, Taylor A., Haslehurst, Peter, James, Owain T., Yap, Kenrick, Muessig, Laurenz, Moroni, Fabia, Nahaboo Solim, Muzammil A., Baidildinova, Gaukhar, Wang, Rui, Richardson, Jill C., Cacucci, Francesca, Salih, Dervis A., Cummings, Damian M., Edwards, Frances A.
Format: Artigo
Language:Inglês
Published: Elsevier 2018
Subjects:
Research paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354711/
https://ncbi.nlm.nih.gov/pubmed/30555043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.006
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items