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Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APP(Swe)/PSEN1(M146V) transgenic mice
BACKGROUND: Progression of Alzheimer's disease is thought initially to depend on rising amyloidβ and its synaptic interactions. Transgenic mice (TASTPM; APP(Swe)/PSEN1(M146V)) show altered synaptic transmission, compatible with increased physiological function of amyloidβ, before plaques are de...
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| Publicado no: | EBioMedicine |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6354711/ https://ncbi.nlm.nih.gov/pubmed/30555043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.006 |
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