Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APP(Swe)/PSEN1(M146V) transgenic mice

BACKGROUND: Progression of Alzheimer's disease is thought initially to depend on rising amyloidβ and its synaptic interactions. Transgenic mice (TASTPM; APP(Swe)/PSEN1(M146V)) show altered synaptic transmission, compatible with increased physiological function of amyloidβ, before plaques are de...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Medawar, Evelyn, Benway, Tiffanie A., Liu, Wenfei, Hanan, Taylor A., Haslehurst, Peter, James, Owain T., Yap, Kenrick, Muessig, Laurenz, Moroni, Fabia, Nahaboo Solim, Muzammil A., Baidildinova, Gaukhar, Wang, Rui, Richardson, Jill C., Cacucci, Francesca, Salih, Dervis A., Cummings, Damian M., Edwards, Frances A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354711/
https://ncbi.nlm.nih.gov/pubmed/30555043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.006
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