Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APP(Swe)/PSEN1(M146V) transgenic mice

BACKGROUND: Progression of Alzheimer's disease is thought initially to depend on rising amyloidβ and its synaptic interactions. Transgenic mice (TASTPM; APP(Swe)/PSEN1(M146V)) show altered synaptic transmission, compatible with increased physiological function of amyloidβ, before plaques are de...

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Dades bibliogràfiques
Publicat a:EBioMedicine
Autors principals: Medawar, Evelyn, Benway, Tiffanie A., Liu, Wenfei, Hanan, Taylor A., Haslehurst, Peter, James, Owain T., Yap, Kenrick, Muessig, Laurenz, Moroni, Fabia, Nahaboo Solim, Muzammil A., Baidildinova, Gaukhar, Wang, Rui, Richardson, Jill C., Cacucci, Francesca, Salih, Dervis A., Cummings, Damian M., Edwards, Frances A.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
Matèries:
Research paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354711/
https://ncbi.nlm.nih.gov/pubmed/30555043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.006
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