The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

Amyloidogenic processing of the amyloid precursor protein (APP) by β- and γ-secretases generates several biologically active products, including amyloid-β (Aβ) and the APP intracellular domain (AICD). AICD regulates transcription of several neuronal genes, especially the Aβ-degrading enzyme, neprily...

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Detalhes bibliográficos
Main Authors: Belyaev, Nikolai D., Kellett, Katherine A. B., Beckett, Caroline, Makova, Natalia Z., Revett, Timothy J., Nalivaeva, Natalia N., Hooper, Nigel M., Turner, Anthony J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009870/
https://ncbi.nlm.nih.gov/pubmed/20961856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.141390
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