Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

Amyloid β-peptide (Aβ) accumulation leads to neurodegeneration and Alzheimer disease; however, amyloid metabolism is a dynamic process and enzymic mechanisms exist for Aβ removal. Considerable controversy surrounds whether the intracellular domain of the amyloid precursor protein (AICD) regulates ex...

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Bibliographic Details
Main Authors: Belyaev, Nikolai D, Nalivaeva, Natalia N, Makova, Natalia Z, Turner, Anthony J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2009
Subjects:
Scientific Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613207/
https://ncbi.nlm.nih.gov/pubmed/19057576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.222
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