Over–expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's–like deficits in mice modeling the disease

Rapamycin, an inhibitor of target-of-rapamycin, extends lifespan in mice, possibly by delaying aging. We recently showed that rapamycin halts the progression of Alzheimer’s (AD)-like deficits, reduces amyloid-beta (Aβ) and induces autophagy in the human amyloid precursor protein (PDAPP) mouse model....

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Vydáno v:J Neurochem
Hlavní autoři: Pierce, Anson, Podlutskaya, Natalia, Halloran, Jonathan J., Hussong, Stacy A., Lin, Pei-Yi, Burbank, Raquel, Hart, Matthew J., Galvan, Veronica
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762020/
https://ncbi.nlm.nih.gov/pubmed/23121022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12080
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