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Rapamycin and Alzheimer’s disease: Time for a clinical trial?

The drug rapamycin has beneficial effects in a number of animal models of neurodegeneration and aging including mouse models of Alzheimer’s disease. Despite its compelling preclinical record, no clinical trials have tested rapamycin or other mTOR inhibitors in patients with Alzheimer’s disease. We a...

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Detalles Bibliográficos
Publicado en:Sci Transl Med
Autores principales: Kaeberlein, Matt, Galvan, Veronica
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762017/
https://ncbi.nlm.nih.gov/pubmed/30674654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aar4289
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