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CENP-A Ubiquitylation Is Indispensable to Cell Viability

CENP-A is a centromere-specific histone H3 variant that epigenetically determines centromere identity, but how CENP-A is deposited at the centromere remains obscure. We previously reported that CENP-A K124 ubiquitylation, mediated by the CUL4A-RBX1-COPS8 complex, is essential for CENP-A deposition a...

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Bibliografski detalji
Izdano u:Dev Cell
Glavni autori: Niikura, Yohei, Kitagawa, Risa, Fang, Lei, Kitagawa, Katsumi
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761987/
https://ncbi.nlm.nih.gov/pubmed/31550462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.07.015
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