Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa

Emergence of resistance to polymyxins in Pseudomonas aeruginosa is mainly due to mutations in two-component systems that promote the addition of 4-amino-4-deoxy-l-arabinose to the lipopolysaccharide (LPS) through upregulation of operon arnBCADTEF-ugd (arn) expression. Here, we demonstrate that mutat...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Bolard, Arnaud, Schniederjans, Monika, Haüssler, Susanne, Triponney, Pauline, Valot, Benoît, Plésiat, Patrick, Jeannot, Katy
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761568/
https://ncbi.nlm.nih.gov/pubmed/31383668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01044-19
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