Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa

Emergence of resistance to polymyxins in Pseudomonas aeruginosa is mainly due to mutations in two-component systems that promote the addition of 4-amino-4-deoxy-l-arabinose to the lipopolysaccharide (LPS) through upregulation of operon arnBCADTEF-ugd (arn) expression. Here, we demonstrate that mutat...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Bolard, Arnaud, Schniederjans, Monika, Haüssler, Susanne, Triponney, Pauline, Valot, Benoît, Plésiat, Patrick, Jeannot, Katy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761568/
https://ncbi.nlm.nih.gov/pubmed/31383668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01044-19
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