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A Two-Component Regulatory System Interconnects Resistance to Polymyxins, Aminoglycosides, Fluoroquinolones, and β-Lactams in Pseudomonas aeruginosa

Constitutive overexpression of the active efflux system MexXY/OprM is a major cause of resistance to aminoglycosides, fluoroquinolones, and cefepime in clinical strains of Pseudomonas aeruginosa. Upregulation of this pump often results from mutations occurring in mexZ, the local repressor gene of th...

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Bibliografiske detaljer
Main Authors: Muller, Cédric, Plésiat, Patrick, Jeannot, Katy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067119/
https://ncbi.nlm.nih.gov/pubmed/21149619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01252-10
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