Pyrrolomycins Are Potent Natural Protonophores

The escalating burden of antibiotic drug resistance necessitates research into novel classes of antibiotics and their mechanism of action. Pyrrolomycins are a family of potent natural product antibiotics with nanomolar activity against Gram-positive bacteria, yet with an elusive mechanism of action....

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Valderrama, Katherine, Pradel, Elizabeth, Firsov, Alexander M., Drobecq, Hervé, Bauderlique-le Roy, Hélène, Villemagne, Baptiste, Antonenko, Yuri N., Hartkoorn, Ruben Christiaan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761498/
https://ncbi.nlm.nih.gov/pubmed/31405863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01450-19
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