Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents

Bacterial enoyl-acyl carrier protein (ACP) reductase (FabI) catalyzes the final step in each elongation cycle of bacterial fatty acid biosynthesis and is an attractive target for the development of new antibacterial agents. High-throughput screening of the Staphylococcus aureus FabI enzyme identifie...

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Detalhes bibliográficos
Main Authors: Payne, David J., Miller, William H., Berry, Valerie, Brosky, John, Burgess, Walter J., Chen, Emile, DeWolf, Jr., Walter E., Fosberry, Andrew P., Greenwood, Rebecca, Head, Martha S., Heerding, Dirk A., Janson, Cheryl A., Jaworski, Deborah D., Keller, Paul M., Manley, Peter J., Moore, Terrance D., Newlander, Kenneth A., Pearson, Stewart, Polizzi, Brian J., Qiu, Xiayang, Rittenhouse, Stephen F., Slater-Radosti, Courtney, Salyers, Kevin L., Seefeld, Mark A., Smyth, Martin G., Takata, Dennis T., Uzinskas, Irene N., Vaidya, Kalindi, Wallis, Nicola G., Winram, Scott B., Yuan, Catherine C. K., Huffman, William F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC128775/
https://ncbi.nlm.nih.gov/pubmed/12234833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.10.3118-3124.2002
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