Emergence of resistance to tyrosine kinase inhibitors in non-small-cell lung cancer can be delayed by an upfront combination with the HSP90 inhibitor onalespib

Por Courtin, Aurelie, Smyth, Tomoko, Hearn, Keisha, Saini, Harpreet K, Thompson, Neil T, Lyons, John F, Wallis, Nicola G
Publicado no Br J Cancer (2016)

Two Active Forms of UDP-N-Acetylglucosamine Enolpyruvyl Transferase in Gram-Positive Bacteria

Por Du, Wensheng, Brown, James R., Sylvester, Daniel R., Huang, Jianzhong, Chalker, Alison F., So, Chi Y., Holmes, David J., Payne, David J., Wallis, Nicola G.
Publicado em 2000

Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).

Por Marrakchi, Hedia, Dewolf, Walter E, Quinn, Chad, West, Joshua, Polizzi, Brian J, So, Chi Y, Holmes, David J, Reed, Shannon L, Heath, Richard J, Payne, David J, Rock, Charles O, Wallis, Nicola G
Publicado em 2003

Inhibition of HSP90 by AT13387 Delays the Emergence of Resistance to BRAF Inhibitors and Overcomes Resistance to dual BRAF and MEK Inhibition in Melanoma Models

Por Smyth, Tomoko, Paraiso, Kim H T, Hearn, Keisha, Rodriguez-Lopez, Ana M, Munck, Joanne M, Haarberg, H Eirik, Sondak, Vernon K, Thompson, Neil T, Azab, Mohammad, Lyons, John F, Smalley, Keiran S M, Wallis, Nicola G
Publicado no Mol Cancer Ther (2014)

The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models

Por Smyth, Tomoko, Van Looy, Thomas, Curry, Jayne E., Rodriguez-Lopez, Ana M., Wozniak, Agnieszka, Zhu, Meijun, Donsky, Rachel, Morgan, Jennifer G., Mayeda, Mark, Fletcher, Jonathan A., Schöffski, Patrick, Lyons, John, Thompson, Neil T., Wallis, Nicola G.
Publicado em 2012

Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates of Staphylococcus aureus

Por Fan, Frank, Yan, Kang, Wallis, Nicola G., Reed, Shannon, Moore, Terrance D., Rittenhouse, Stephen F., DeWolf, Jr., Walter E., Huang, Jianzhong, McDevitt, Damien, Miller, William H., Seefeld, Mark A., Newlander, Kenneth A., Jakas, Dalia R., Head, Martha S., Payne, David J.
Publicado em 2002

Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents

Por Payne, David J., Miller, William H., Berry, Valerie, Brosky, John, Burgess, Walter J., Chen, Emile, DeWolf, Jr., Walter E., Fosberry, Andrew P., Greenwood, Rebecca, Head, Martha S., Heerding, Dirk A., Janson, Cheryl A., Jaworski, Deborah D., Keller, Paul M., Manley, Peter J., Moore, Terrance D., Newlander, Kenneth A., Pearson, Stewart, Polizzi, Brian J., Qiu, Xiayang, Rittenhouse, Stephen F., Slater-Radosti, Courtney, Salyers, Kevin L., Seefeld, Mark A., Smyth, Martin G., Takata, Dennis T., Uzinskas, Irene N., Vaidya, Kalindi, Wallis, Nicola G., Winram, Scott B., Yuan, Catherine C. K., Huffman, William F.
Publicado em 2002