Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1(P29S) Melanoma Cells

Actin assembly supplies the structural framework for cell morphology and migration. Beyond structure, this actin framework can also be engaged to drive biochemical signaling programs. Here, we describe how the hyperactivation of Rac1 via the P29S mutation (Rac1(P29S)) in melanoma hijacks branched ac...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Dev Cell
Main Authors: Mohan, Ashwathi S., Dean, Kevin M., Isogai, Tadamoto, Kasitinon, Stacy Y., Murali, Vasanth S., Roudot, Philippe, Groisman, Alex, Reed, Dana K., Welf, Erik S., Han, Sangyoon J., Noh, Jungsik, Danuser, Gaudenz
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760970/
https://ncbi.nlm.nih.gov/pubmed/31063759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.04.007
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki