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Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation
The Rho-GTPase Rac1 stimulates actin remodelling at the cell periphery by relaying signals to Scar/WAVE proteins leading to activation of Arp2/3-mediated actin polymerization. Scar/WAVE proteins do not interact with Rac1 directly, but instead assemble into multiprotein complexes, which was shown to...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC380996/ https://ncbi.nlm.nih.gov/pubmed/14765121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600084 |
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