Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1(P29S) Melanoma Cells

Actin assembly supplies the structural framework for cell morphology and migration. Beyond structure, this actin framework can also be engaged to drive biochemical signaling programs. Here, we describe how the hyperactivation of Rac1 via the P29S mutation (Rac1(P29S)) in melanoma hijacks branched ac...

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Pubblicato in:Dev Cell
Autori principali: Mohan, Ashwathi S., Dean, Kevin M., Isogai, Tadamoto, Kasitinon, Stacy Y., Murali, Vasanth S., Roudot, Philippe, Groisman, Alex, Reed, Dana K., Welf, Erik S., Han, Sangyoon J., Noh, Jungsik, Danuser, Gaudenz
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760970/
https://ncbi.nlm.nih.gov/pubmed/31063759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.04.007
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