Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1(P29S) Melanoma Cells

Actin assembly supplies the structural framework for cell morphology and migration. Beyond structure, this actin framework can also be engaged to drive biochemical signaling programs. Here, we describe how the hyperactivation of Rac1 via the P29S mutation (Rac1(P29S)) in melanoma hijacks branched ac...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Mohan, Ashwathi S., Dean, Kevin M., Isogai, Tadamoto, Kasitinon, Stacy Y., Murali, Vasanth S., Roudot, Philippe, Groisman, Alex, Reed, Dana K., Welf, Erik S., Han, Sangyoon J., Noh, Jungsik, Danuser, Gaudenz
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760970/
https://ncbi.nlm.nih.gov/pubmed/31063759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.04.007
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