Potency, Efficacy, and Selectivity of GR64349 at Human Recombinant Neurokinin NK2 and NK1 Receptors

The affinity, potency, efficacy, and selectivity of the NK2 receptor agonist GR64349 ([Lys(3),Gly(8),-R-γ-lactam-Leu(9)]-NKA(3-10)) at human recombinant NK2 and NK1 receptors was examined. In radioligand binding studies, GR64349 displaced [(125)I]-NKA binding to NK2 receptors with high affinity (pKi...

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Detalhes bibliográficos
Publicado no:Neurosci Lett
Main Authors: Perdona, Elisabetta, Cavallini, Palmina, Sava, Anna, Griffante, Cristiana, Ricca, Daniel J., Thor, Karl B., Rupniak, Nadia M.J., Corsi, Mauro
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759388/
https://ncbi.nlm.nih.gov/pubmed/31445972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2019.134456
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