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Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in βArrestin-2 Knock-Out Mice
Morphine induces antinociception by activating μ opioid receptors (μORs) in spinal and supraspinal regions of the CNS. βarrestin-2 (βarr2), a G-protein-coupled receptor-regulating protein, regulates the μOR in vivo. We have shown previously that mice lacking βarr2 experience enhanced morphine-induce...
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| 發表在: | J Neurosci |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Society for Neuroscience
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6758751/ https://ncbi.nlm.nih.gov/pubmed/12451149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-23-10494.2002 |
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