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Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in βArrestin-2 Knock-Out Mice

Morphine induces antinociception by activating μ opioid receptors (μORs) in spinal and supraspinal regions of the CNS. βarrestin-2 (βarr2), a G-protein-coupled receptor-regulating protein, regulates the μOR in vivo. We have shown previously that mice lacking βarr2 experience enhanced morphine-induce...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Bohn, Laura M., Lefkowitz, Robert J., Caron, Marc G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2002
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758751/
https://ncbi.nlm.nih.gov/pubmed/12451149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-23-10494.2002
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