Insulin-Like Growth Factor-I Blocks Bcl-2 Interacting Mediator of Cell Death (Bim) Induction and Intrinsic Death Signaling in Cerebellar Granule Neurons

Cerebellar granule neurons depend on insulin-like growth factor-I (IGF-I) for their survival. However, the mechanism underlying the neuroprotective effects of IGF-I is presently unclear. Here we show that IGF-I protects granule neurons by suppressing key elements of the intrinsic (mitochondrial) dea...

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Publicado no:J Neurosci
Main Authors: Linseman, Daniel A., Phelps, Reid A., Bouchard, Ron J., Le, Shoshona S., Laessig, Tracey A., McClure, Maria L., Heidenreich, Kim A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758065/
https://ncbi.nlm.nih.gov/pubmed/12417654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-21-09287.2002
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