The p75 Neurotrophin Receptor Can Induce Autophagy and Death of Cerebellar Purkinje Neurons

The cellular mechanisms underlying Purkinje neuron death in various neurodegenerative disorders of the cerebellum are poorly understood. Here we investigate an in vitro model of cerebellar neuronal death. We report that cerebellar Purkinje neurons, deprived of trophic factors, die by a form of progr...

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Hlavní autoři: Florez-McClure, Maria L., Linseman, Daniel A., Chu, Charleen T., Barker, Phil A., Bouchard, Ron J., Le, Shoshona S., Laessig, Tracey A., Heidenreich, Kim A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2004
Témata:
Cellular/Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876689/
https://ncbi.nlm.nih.gov/pubmed/15140920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5744-03.2004
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