Glycogen Synthase Kinase-3β Phosphorylates Bax and Promotes Its Mitochondrial Localization during Neuronal Apoptosis

Glycogen synthase kinase-3β (GSK-3β) is a critical activator of neuronal apoptosis induced by a diverse array of neurotoxic insults. However, the downstream substrates of GSK-3β that ultimately induce neuronal death are unknown. Here, we show that GSK-3β phosphorylates and regulates the activity of...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Linseman, Daniel A., Butts, Brent D., Precht, Thomas A., Phelps, Reid A., Le, Shoshona S., Laessig, Tracey A., Bouchard, Ron J., Florez-McClure, Maria L., Heidenreich, Kim A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730230/
https://ncbi.nlm.nih.gov/pubmed/15525785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2057-04.2004
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