Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons

Rho GTPases are key transducers of integrin/extracellular matrix and growth factor signaling. Although integrin-mediated adhesion and trophic support suppress neuronal apoptosis, the role of Rho GTPases in neuronal survival is unclear. Here, we have identified Rac as a critical pro-survival GTPase i...

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Detalhes bibliográficos
Main Authors: Le, Shoshona S., Loucks, F. Alexandra, Udo, Hiroshi, Richardson-Burns, Sarah, Phelps, Reid A., Bouchard, Ron J., Barth, Holger, Aktories, Klaus, Tyler, Kenneth L., Kandel, Eric R., Heidenreich, Kim A., Linseman, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2366110/
https://ncbi.nlm.nih.gov/pubmed/16092944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2005.03252.x
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