Calpain Plays a Central Role in 1-Methyl-4-phenylpyridinium (MPP(+))-Induced Neurotoxicity in Cerebellar Granule Neurons

1-Methyl-4-phenylpyridinium (MPP(+))-induced neurotoxicity has previously been attributed to either caspase-dependent apoptosis or caspase-independent cell death. In the current study, we found that MPP(+) induces a unique, non-apoptotic nuclear morphology coupled with a caspase-independent but calp...

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Pubblicato in:Neurotox Res
Autori principali: Harbison, Richard A., Ryan, Kristen R., Wilkins, Heather M., Schroeder, Emily K., Loucks, F. Alexandra, Bouchard, Ron J., Linseman, Daniel A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8061704/
https://ncbi.nlm.nih.gov/pubmed/20333497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12640-010-9172-4
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