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Coupled and Uncoupled Gating and Desensitization Effects by Pore Domain Mutations in GABA(A) Receptors

GABA(A) receptors are allosteric ligand-gated ion channels. Agonist-induced gating and desensitization have been proposed to be coupled via pore domain structures. Mutations at two α(1) subunit pore-domain (transmembrane domain 2) residues enhance GABA sensitivity, leucine-to-threonine at position 2...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Scheller, Michaela, Forman, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757762/
https://ncbi.nlm.nih.gov/pubmed/12351715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-19-08411.2002
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