Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABA(A) receptor desensitization and deactivation

The time course of inhibitory postsynaptic currents (IPSCs) reflects GABA(A) receptor deactivation, the process of current relaxation following transient activation. Fast desensitization has been demonstrated to prolong deactivation, and these processes have been described as being ‘coupled’. Howeve...

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Autores principales: Bianchi, Matt T, Botzolakis, Emmanuel J, Haas, Kevin F, Fisher, Janet L, Macdonald, Robert L
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2007
Materias:
Cellular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276985/
https://ncbi.nlm.nih.gov/pubmed/17884921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.142364
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