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Enhanced macroscopic desensitization shapes the response of α4 subtype-containing GABA(A) receptors to synaptic and extrasynaptic GABA

Up-regulation of the GABA(A) receptor α4 subunit subtype has been consistently shown in multiple animal models of chronic epilepsy. This isoform is expressed in both thalamus and hippocampus and is likely to play a significant role in regulating corticothalamic and hippocampal rhythms. However, litt...

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Detalhes bibliográficos
Main Authors: Lagrange, Andre H, Botzolakis, Emmanuel J, Macdonald, Robert L
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151343/
https://ncbi.nlm.nih.gov/pubmed/17124266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.122135
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