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Modulation of GABA(A) receptor desensitization uncouples sleep onset and maintenance in Drosophila

Many lines of evidence indicate that GABA and GABA(A) receptors make important contributions to human sleep regulation. Pharmacological manipulation of these receptors has differential effects on sleep onset and sleep maintenance insomnia. Here we show that sleep is regulated by GABA in Drosophila a...

詳細記述

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書誌詳細
主要な著者: Agosto, Jose, Choi, James C, Parisky, Katherine M, Stilwell, Geoffrey, Rosbash, Michael, Griffith, Leslie C
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655319/
https://ncbi.nlm.nih.gov/pubmed/18223647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn2046
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