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Massively parallel RNA device engineering in mammalian cells with RNA-Seq

Synthetic RNA-based genetic devices dynamically control a wide range of gene-regulatory processes across diverse cell types. However, the limited throughput of quantitative assays in mammalian cells has hindered fast iteration and interrogation of sequence space needed to identify new RNA devices. H...

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Vydáno v:Nat Commun
Hlavní autoři: Xiang, Joy S., Kaplan, Matias, Dykstra, Peter, Hinks, Michaela, McKeague, Maureen, Smolke, Christina D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757056/
https://ncbi.nlm.nih.gov/pubmed/31548547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12334-y
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