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Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates

Methods have been developed for Mendelian randomization that can obtain consistent causal estimates under weaker assumptions than the standard instrumental variable assumptions. The median-based estimator and MR-Egger are examples of such methods. However, these methods can be sensitive to genetic v...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Rees, Jessica M. B., Wood, Angela M., Dudbridge, Frank, Burgess, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756542/
https://ncbi.nlm.nih.gov/pubmed/31545794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222362
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