Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation

Tripartite motif-containing protein 65 (TRIM65) is an E3 ubiquitin ligase and a critical regulator of a variety of cellular processes as well as tumor progression. Therefore, more substrates must be identified in the physiology or disease context. Here, we found that TRIM65 is upregulated and associ...

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Veröffentlicht in:Oncogene
Hauptverfasser: Chen, Daici, Li, Yichen, Zhang, Xiaowen, Wu, Haiyong, Wang, Qian, Cai, Jian, Cui, Yanmei, Liu, Huanliang, Lan, Ping, Wang, Jianping, Yang, Zihuan, Wang, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756236/
https://ncbi.nlm.nih.gov/pubmed/31332286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0891-6
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