MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1

Genome instability is a common feature of tumor cells, and the persistent presence of genome instability is a potential mechanism of tumorigenesis. The E3 ubiquitin ligase MDM2 is intimately involved in genome instability, but its mechanisms are unclear. Our data demonstrated that the transcription...

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Bibliographic Details
Published in:Oncogene
Main Authors: Cao, Zhengyi, Xue, Junhui, Cheng, Yuning, Wang, Jiyin, Liu, Yujuan, Li, Hui, Jiang, Wei, Li, Gang, Gui, Yaoting, Zhang, Xiaowei
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756050/
https://ncbi.nlm.nih.gov/pubmed/30816344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0761-2
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