HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis

The activity of the CDK inhibitor p21 is associated with diverse biological activities, including cell proliferation, senescence, and tumorigenesis. However, the mechanisms governing transcription of p21 need to be extensively studied. In this study, we demonstrate that the high-mobility group box-c...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chen, Yifan, Pan, Kewu, Wang, Pingzhang, Cao, Zhengyi, Wang, Weibin, Wang, Shuya, Hu, Ningguang, Xue, Junhui, Li, Hui, Jiang, Wei, Li, Gang, Zhang, Xiaowei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933444/
https://ncbi.nlm.nih.gov/pubmed/27129219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.714147
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