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PIASxα Ligase Enhances SUMO1 Modification of PTEN Protein as a SUMO E3 Ligase
The tumor suppressor PTEN plays a critical role in the regulation of multiple cellular processes that include survival, cell cycle, proliferation, and apoptosis. PTEN is frequently mutated or deleted in various human cancer cells to promote tumorigenesis. PTEN is regulated by SUMOylation, but the SU...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3916526/ https://ncbi.nlm.nih.gov/pubmed/24344134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508515 |
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