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Systematic minimization of RNA ligase ribozyme through large-scale design-synthesis-sequence cycles

Template-directed RNA ligation catalyzed by an RNA enzyme (ribozyme) is a plausible and important reaction that could have been involved in transferring genetic information during prebiotic evolution. Laboratory evolution experiments have yielded several classes of ligase ribozymes, but their minima...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Nucleic Acids Res
Main Authors: Nomura, Yoko, Yokobayashi, Yohei
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6755084/
https://ncbi.nlm.nih.gov/pubmed/31504757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz729
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