Phosphorylated claudin-16 interacts with Trpv5 and regulates transcellular calcium transport in the kidney

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) was previously considered to be a paracellular channelopathy caused by mutations in the claudin-16 and claudin-19 genes. Here, we provide evidence that a missense FHHNC mutation c.908C>G (p.T303R) in the claudin-16 gene inte...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Hou, Jianghui, Renigunta, Vijay, Nie, Mingzhu, Sunq, Abby, Himmerkus, Nina, Quintanova, Catarina, Bleich, Markus, Renigunta, Aparna, Wolf, Matthias Tilmann Florian
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754598/
https://ncbi.nlm.nih.gov/pubmed/31488724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902042116
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