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Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity

Accumulative aggregation of mutant Huntingtin (Htt) is a primary neuropathological hallmark of Huntington’s disease (HD). Currently, mechanistic understanding of the cytotoxicity of mutant Htt aggregates remains limited, and neuroprotective strategies combating mutant Htt-induced neurodegeneration a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zhu, Yi, Li, Chong, Tao, Xianzun, Brazill, Jennifer M., Park, Joun, Diaz-Perez, Zoraida, Zhai, R. Grace
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754563/
https://ncbi.nlm.nih.gov/pubmed/31484760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904563116
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