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Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity
Accumulative aggregation of mutant Huntingtin (Htt) is a primary neuropathological hallmark of Huntington’s disease (HD). Currently, mechanistic understanding of the cytotoxicity of mutant Htt aggregates remains limited, and neuroprotective strategies combating mutant Htt-induced neurodegeneration a...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6754563/ https://ncbi.nlm.nih.gov/pubmed/31484760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904563116 |
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