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Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

Nicotinamide mononucleotide adenylyltransferase (NMNAT) is a conserved enzyme in the NAD synthetic pathway. It has also been identified as an effective and versatile neuroprotective factor. However, it remains unclear how healthy neurons regulate the dual functions of NMNAT and achieve self-protecti...

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Publicat a:Nat Commun
Autors principals: Ruan, Kai, Zhu, Yi, Li, Chong, Brazill, Jennifer M., Zhai, R. Grace
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674693/
https://ncbi.nlm.nih.gov/pubmed/26616331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10057
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