The magnitude of IFN-γ responses is fine-tuned by DNA architecture and the non-coding transcript of Ifng-as1

IFN-γ, critical for host defense and tumor surveillance, requires tight control of its expression. Multiple cis-regulatory elements exist around Ifng along with a non-coding transcript, Ifng-as1 (also termed NeST). Here, we describe two genetic models generated to dissect the molecular functions of...

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Publicat a:Mol Cell
Autors principals: Petermann, Franziska, Pękowska, Aleksandra, Johnson, Catrina A., Jankovic, Dragana, Shih, Han-Yu, Jiang, Kan, Hudson, William H., Brooks, Stephen R., Sun, Hong-Wei, Villarino, Alejandro V., Yao, Chen, Singleton, Kentner, Akondy, Rama S., Kanno, Yuka, Sher, Alan, Casellas, Rafael, Ahmed, Rafi, O’Shea, John J.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754279/
https://ncbi.nlm.nih.gov/pubmed/31377117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.025
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