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T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription
T helper type 1 (Th1) development is facilitated by interrelated changes in key intracellular factors, particularly signal transducer and activator of transcription (STAT)4, T-bet, and GATA-3. Here we show that CD4(+) cells from T-bet(−/−) mice are skewed toward Th2 differentiation by high endogenou...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118252/ https://ncbi.nlm.nih.gov/pubmed/16520391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052165 |
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