CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice

Tumors induce tolerance toward their antigens by producing the chemokine CCL21, leading to the formation of tertiary lymphoid organs (TLOs). Ins2-CCL21 transgenic, nonobese diabetic (NOD) mice express CCL21 in pancreatic β-cells and do not develop autoimmune diabetes. We investigated by which mechan...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Gonzalez Badillo, Freddy E., Zisi Tegou, Flavia, Abreu, Maria M., Masina, Riccardo, Sha, Divya, Najjar, Mejdi, Wright, Shane H., Bayer, Allison L., Korpos, Éva, Pugliese, Alberto, Molano, R. Damaris, Tomei, Alice A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2019
Soggetti:
Immunology and Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754241/
https://ncbi.nlm.nih.gov/pubmed/31371518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0239
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