CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice

Tumors induce tolerance toward their antigens by producing the chemokine CCL21, leading to the formation of tertiary lymphoid organs (TLOs). Ins2-CCL21 transgenic, nonobese diabetic (NOD) mice express CCL21 in pancreatic β-cells and do not develop autoimmune diabetes. We investigated by which mechan...

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Dades bibliogràfiques
Publicat a:Diabetes
Autors principals: Gonzalez Badillo, Freddy E., Zisi Tegou, Flavia, Abreu, Maria M., Masina, Riccardo, Sha, Divya, Najjar, Mejdi, Wright, Shane H., Bayer, Allison L., Korpos, Éva, Pugliese, Alberto, Molano, R. Damaris, Tomei, Alice A.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2019
Matèries:
Immunology and Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754241/
https://ncbi.nlm.nih.gov/pubmed/31371518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0239
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