Differential CRE Expression in Lhrh-cre and GnRH-cre Alleles and the Impact on Fertility in Otx2-Flox Mice

There is an increasing trend in studies utilizing cell-specific deletion of genes through conditional gene deletion by CRE recombination. Despite numerous advantages, this strategy also has limitations such as ectopic CRE-expression and germline recombination. Two commonly used gonadotropin-releasin...

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Gepubliceerd in:Neuroendocrinology
Hoofdauteurs: Hoffmann, Hanne M., Larder, Rachel, Lee, Jessica S., Hu, Rachael J., Trang, Crystal, Devries, Brooke M., Clark, Daniel D., Mellon, Pamela L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753941/
https://ncbi.nlm.nih.gov/pubmed/30739114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000497791
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