Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility

Hypothalamic GnRH (luteinizing hormone–releasing hormone) neurons are crucial for the hypothalamic-pituitary-gonadal (HPG) axis, which regulates mammalian fertility. Insufficient GnRH disrupts the HPG axis and is often associated with the genetic condition idiopathic hypogonadotropic hypogonadism (I...

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Detaylı Bibliyografya
Yayımlandı:Endocrinology
Asıl Yazarlar: Pandolfi, Erica C, Tonsfeldt, Karen J, Hoffmann, Hanne M, Mellon, Pamela L
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821215/
https://ncbi.nlm.nih.gov/pubmed/31211355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00113
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