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Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility

Hypothalamic gonadotropin-releasing hormone (GnRH) neurons are at the apex of the hypothalamic-pituitary-gonadal axis that regulates mammalian fertility. Herein we demonstrate a critical role for the homeodomain transcription factor ventral anterior homeobox 1 (VAX1) in GnRH neuron maturation and sh...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Hoffmann, Hanne M., Trang, Crystal, Gong, Ping, Kimura, Ikuo, Pandolfi, Erica C., Mellon, Pamela L.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804008/
https://ncbi.nlm.nih.gov/pubmed/27013679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2723-15.2016
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