Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subunits complexed with FK506 and the FK506-binding pr...

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Publicado no:Nat Commun
Main Authors: Juvvadi, Praveen R., Fox, David, Bobay, Benjamin G., Hoy, Michael J., Gobeil, Sophie M. C., Venters, Ronald A., Chang, Zanetta, Lin, Jackie J., Averette, Anna Floyd, Cole, D. Christopher, Barrington, Blake C., Wheaton, Joshua D., Ciofani, Maria, Trzoss, Michael, Li, Xiaoming, Lee, Soo Chan, Chen, Ying-Lien, Mutz, Mitchell, Spicer, Leonard D., Schumacher, Maria A., Heitman, Joseph, Steinbach, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753081/
https://ncbi.nlm.nih.gov/pubmed/31537789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12199-1
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